
Grant Project Title:
Examining mechanisms for the differential risk of hypertensive disorders of pregnancy in spontaneous versus ART pregnancies
Grant Amount:
$750,000
Significance:
High blood pressure during pregnancy is a leading cause of maternal and infant mortality. Often, it develops silently until late in pregnancy, and when it does present, it requires urgent access to care and timely delivery. Certain groups—such as older women, those with obesity, and individuals who conceive using assisted reproductive technology (ART)—are at a significantly higher risk for pregnancy-related blood pressure complications. This research aims to study specific markers in the blood, called exosomes, collected from pregnant women around 8–10 weeks of gestation. By comparing pregnancies conceived spontaneously with those conceived through ART, we hope to better understand why ART pregnancies are more prone to blood pressure-related issues. Early identification of women at higher risk can help ensure they receive specialized prenatal care in a timely manner—care that could mean the difference between life and death for both mother and baby.
With deep gratitude, I thank ASRM research institute for the vital support that this award has allowed. This investment in our efforts and the trust placed in me and my team have been a tide turner in lifting hearts, sharpening minds, and rekindling our imaginative torches! It is allowing a weaving of vibrant threads with renewed vitality, has kindled momentum, elevated morale and truly has added meaning across every facet of our team’s work!
Lubna Pal, MBBS, MRCOG (UK), MS
Professor
Department of Obstetrics, Gynecology & Reproductive Sciences
Yale School of Medicine